The building was founded by the will of the Magnificent Lord Mark Zacco who commissioned, December 19, 1555, the purchase of stones for the construction of the building. Mark Zacco, for manufacturing design, called Bergamo Andrea Moroni (the architect, in Padua, he devoted himself to various projects: the university courtyard, the botanical garden, the loggia of Capitaniato square, as well as those of Renaissance restructuring the palazzo del Podesta - current City Hall - and the basilica of Santa Giustina). In January 1557 the construction work ended, allowing all the nobility Zacco to dwell in the palace for nearly three hundred years. After the fall of the Venetian Republic (1797), Padua was alternately occupied by the French and the Austrians. In 1813 they returned rulers and the Austrians in 1819, during the United Lombardo-Veneto (made April 7, 1815), the Austrian Emperor Francis I (Francis Joseph Karl von Habsburg) stayed in the palace with his fourth wife , Archduchess Caroline Augusta of Bavaria.